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KMID : 0614620020400060355
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Korean Journal of Gastroenterology
2002 Volume.40 No. 6 p.355 ~ p.363
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Expression of Integrin α5, α6, αV, β1, β2, β3, β4 Subunits in Gastric Cancer
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Gham Chang-Woo
Park Seung-Woo
Shin Yule
Kim Hyun-Wook
Kim Han-Soo
Song Si-Young
Chung Jae-Bock
Kang Jin-Kyung
Noh Sung-Hoon
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Abstract
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Background/Aims: The intergrins play a central role in maintaining the morphology of cell and tissue, growth, differentiation, migration, survival and apoptosis of cells, and angiogenesis. Although integrins are implicated in carcinogenesis and tumor angiogenesis, their precise contributions to the process are largely unknown.
Methods: For paraffin embedded tissue samples of 102 gastric cancers (23 differentiated, 79 undifferentiated), the expression of integrin α5,α6, αV, β1, β2, β3, β4 subunits and factor Ⅷ were examined by immunohistochemical staining.
The relationships between the expression of each integrin and several clinicopathologic parameters were analyzed.
Results: The positive rates of integrins were as follows: α5 24%, β1 8%, α6 16%, β4 24%, αV 29%, and β3 34%. The expression of α5, α6, and αV was well correlated with the the expression of β1, β4 and β3, respectively. The αV
integrin was highly expressed in tumors of advanced T stage. The expression of α6 and β4 integrins were significantly higher in differentiated tumors, but the β3 integrin was significantly expressed in undifferentiated tumors. The number of tumor vessels has positive correlation with αV integrin expression.
Conclusions: These findings suggest that integin α6, β4 is one of the key factors in determining tumor differentiation and growth pattern. The integrin αV β3 may be related to hte angiogenesis especially in advanced gastric cancer.
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KEYWORD
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Stomach neoplasms, Intergin, Immunohistochemical stain
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